The Poldi Pezzoli Museum holds over 6,200 inventoried objects. Among its main activities are: conservation and restoration of works, exposure of the same according to the most up-to-date museographic criteria, acquisition of new works and entire collections, study, development of educational activities aimed at all categories of public. In recent years, great importance has been given to the communication of initiatives promoted by the museum through social media and the internet.

House museums are appropriately titled as they tell not only the personal, social, economic, dynastic, collecting, and entrepreneurial tales of their residents but also the history and culture of their eras and the geography of the area in which they are strongly anchored. In 2008, the city of Milan set up the Network of Milan's Historic Houses, a group of museums that tell the stories of the city's most famous people to show off its rich artistic, cultural, and historical history. With the House Museum Card, get to visit Bagatti Valsecchi Museum, Poldi Pezzoli Museum, Villa Necchi Campiglio, and Boschi Di Stefano House Museum. Decorated in period style, the rooms evoke a sense of the past and display priceless artifacts, furniture, and decorative accessories made of valuable materials like gold and silver. These unique collections were given to the city by their owners, who spent their whole lives collecting and celebrating the city's cultural history.